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Related Experiment Video

Updated: Jun 28, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Characterizing white matter connectome abnormalities in patients with temporal lobe epilepsy using threshold-free

Daniel Y Chu^1,2, Theodore P Imhoff-Smith¹, Veena A Nair¹

¹Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Brain and Behavior

|August 5, 2024

Summary

Temporal lobe epilepsy (TLE) is linked to widespread white matter connectome changes. These brain network abnormalities correlate with cognitive impairment and a history of focal-to-bilateral tonic-clonic (FBTC) seizures in TLE patients.

Keywords:

cognitive impairment connectome diffusion‐weighted imaging generalized tonic–clonic seizures temporal lobe epilepsy

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Last Updated: Jun 28, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

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Published on: August 5, 2014

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

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Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Published on: November 1, 2019

Area of Science:

Neuroimaging
Epilepsy Research
Connectomics

Background:

Temporal lobe epilepsy (TLE) involves network disruptions, including hyperexcitability and neural plasticity, but these associations require further characterization.
Understanding TLE's impact on brain networks is crucial for developing targeted therapies.

Purpose of the Study:

To characterize whole-brain white matter connectome abnormalities in TLE patients compared to healthy controls (HCs).
To assess the relationship between aberrant white matter connections and cognitive impairment.
To investigate the association between white matter abnormalities and a history of focal-to-bilateral tonic-clonic (FBTC) seizures.

Main Methods:

Multi-shell connectome MRI data from 142 subjects (92 TLE, 50 HCs) were analyzed.
Structural connectivity matrices (SCMs) were derived and harmonized using ComBat.
Network-based statistics and graph theory measures were employed to analyze white matter integrity and connectivity.

Main Results:

TLE patients exhibited significantly decreased white matter tract cross-sectional area (CSA) compared to HCs, indicating reduced integrity and connectivity.
Abnormalities in the white matter connectome were more pronounced in TLE patients with cognitive impairment.
A trend towards decreased CSA was observed in patients with a history of FBTC seizures.

Conclusions:

Widespread aberrant white matter connectome changes are characteristic of TLE.
These changes are associated with seizure history and cognitive impairment in TLE.
Findings provide a foundation for novel biomarker development and further understanding of TLE's impact on brain plasticity.