Related Experiment Video
Updated: Jun 18, 2025

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties
Published on: September 27, 2020
Neurodevelopmental and Mental Health Conditions in Children With Medical Complexity
JoAnna K Leyenaar1,2, Mary Arakelyan1, Andrew P Schaefer2
1Department of Pediatrics, Children's Hospital at Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.
Insights
Neurodevelopmental and mental health diagnoses are common in children with medical complexity (CMC), significantly increasing their healthcare use. Early recognition and treatment of these conditions in CMC are crucial for better outcomes.
Area of Science:
- Pediatric Health
- Neurodevelopmental Disorders
- Mental Health Conditions
Background:
- Children with medical complexity (CMC) face heightened risks for neurodevelopmental and mental health issues due to comorbidities and unique life experiences.
- Population-level data on the prevalence of these conditions in CMC remains limited.
- Understanding these prevalence rates is critical for targeted interventions.
Purpose of the Study:
- To estimate the prevalence of neurodevelopmental and mental health diagnoses in CMC compared to children without medical complexity.
- To examine the association between these diagnoses in CMC and subsequent healthcare utilization and in-hospital mortality.
Main Methods:
- Utilized all-payer claims data from three states (2012-2017).
- Applied the Child and Adolescent Mental Health Disorders Classification System for diagnosis identification.
- Employed Poisson regression to compare outcomes, adjusting for sociodemographic and clinical factors.
Main Results:
- 45.6% of CMC had neurodevelopmental diagnoses; 37.0% had mental health diagnoses.
- CMC with these diagnoses showed significantly higher relative risks compared to children without medical complexity.
- CMC with both types of diagnoses experienced substantially increased healthcare utilization, including ambulatory visits, emergency department visits, hospitalizations, and hospital days.
Conclusions:
- Neurodevelopmental and mental health diagnoses are highly prevalent in CMC.
- These diagnoses are strongly associated with increased healthcare utilization across all care settings.
- Emphasizes the critical need for identifying and managing these conditions in the CMC population.
Background And Objectives:
Children with medical complexity (CMC) may be at a high risk of neurodevelopmental and mental health conditions given disease comorbidities and lived experiences. Little is known about the prevalence of these conditions at a population level. In this study, we estimated the prevalence of neurodevelopmental and mental health diagnoses in CMC relative to children without medical complexity and measured associations between these diagnoses in CMC and subsequent health care utilization and in-hospital mortality.
Methods:
We applied the Child and Adolescent Mental Health Disorders Classification System to identify neurodevelopmental and mental health diagnoses using all-payer claims data from three states (2012-2017). Poisson regression was used to compare outcomes in CMC with neurodevelopmental and mental health diagnoses to CMC without these diagnoses, adjusting for sociodemographic and clinical characteristics.
Results:
Among 85 581 CMC, 39 065 (45.6%) had ≥1 neurodevelopmental diagnoses, and 31 703 (37.0%) had ≥1 mental health diagnoses, reflecting adjusted relative risks of 3.46 (3.42-3.50) for neurodevelopmental diagnoses and 2.22 (2.19-2.24) for mental health diagnoses compared with children without medical complexity. CMC with both neurodevelopmental and mental health diagnoses had 3.00 (95% confidence interval [CI]: 2.98-3.01) times the number of ambulatory visits, 69% more emergency department visits (rate ratio = 1.69, 95% CI: 1.66-1.72), 58% greater risk of hospitalization (rate ratio = 1.58, 95% CI: 1.50-1.67), and 2.32 times (95% CI: 2.28-2.36) the number of hospital days than CMC without these diagnoses.
Conclusions:
Neurodevelopmental and mental health diagnoses are prevalent among CMC and associated with increased health care utilization across the continuum of care. These findings illustrate the importance of recognizing and treating neurodevelopmental and mental health conditions in this population.
Related Concept Videos
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Specialized Care Centers and Settings-I
Daycare centers
They provide several functions. Some facilities care for healthy newborns and children whose parents work, while others are medically focused and care for...
Intellectual Disability
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Nature and Nurture

