Alternatives for the Detection and Diagnosis of Osteoarticular Infections: An Exploratory Review

Esteban Zavaleta-Monestel1,2, Mariela Alpizar-Rojas3, Jonathan García-Montero4

  • 1Pharmacy, Hospital Clínica Bíblica, San José, CRI.

Cureus
|August 5, 2024
PubMed

Insights

Accurate osteomyelitis diagnosis is challenging. Nuclear medicine offers solutions, but regional shortages necessitate exploring alternative radiopharmaceuticals for better patient care in Costa Rica.

Area of Science:

  • Nuclear Medicine
  • Diagnostic Imaging
  • Infectious Diseases

Background:

  • Osteomyelitis diagnosis presents challenges due to variable clinical presentations.
  • Inaccurate diagnoses lead to suboptimal treatment and complications.
  • Nuclear medicine imaging aids osteomyelitis diagnosis but faces limitations.

Purpose of the Study:

  • To explore alternative nuclear medicine diagnostic approaches for osteomyelitis.
  • To address the regional shortage of gallium-67 (⁶⁷Ga) in Costa Rica.
  • To improve diagnostic accuracy and patient outcomes.

Main Methods:

  • Review of nuclear medicine techniques for osteomyelitis.
  • Evaluation of radiopharmaceuticals, including ⁶⁷Ga and targeted conjugates.
  • Analysis of diagnostic limitations and alternative strategies.

Main Results:

  • Gallium-67 (⁶⁷Ga) scarcity impacts osteomyelitis diagnosis in Costa Rica.
  • Alternative radiopharmaceuticals and targeted imaging show promise.
  • Nuclear medicine offers valuable tools for infection detection.

Conclusions:

  • Alternative diagnostic approaches are crucial due to ⁶⁷Ga shortages.
  • Further research into alternative nuclear medicine techniques is needed.
  • Implementing alternatives can enhance osteomyelitis diagnosis and patient care.