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Shear Wave Elastography in Breast Cancer: Unveiling Correlations With Histopathological Grades and Subtypes
George Asafu Adjaye Frimpong1,2, Evans Aboagye3, Osei Owusu-Afriyie4
1Radiology, Kwame Nkrumah University of Science and Technology, Kumasi, GHA.
Cureus
|August 5, 2024
Summary
Shear wave elastography (SWE) effectively correlates breast cancer stiffness with higher grades and specific subtypes like invasive ductal carcinoma. This imaging technique aids in predicting tumor aggressiveness and improving diagnostic accuracy.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Breast cancer diagnosis relies on imaging and histopathology.
- Shear wave elastography (SWE) offers quantitative tissue stiffness assessment.
- Correlation between SWE features and breast cancer subtypes/grades requires further elucidation.
Purpose of the Study:
- To explore the correlation between shear wave elastography (SWE) features and histopathological grades and subtypes in breast cancer.
- To enhance diagnostic accuracy and inform personalized treatment strategies for breast cancer.
Main Methods:
- Retrospective analysis of 59 breast cancer patients undergoing ultrasound with SWE.
- Recorded SWE parameters, histopathologic information (type, grade), and B-mode findings.
- Assessed sociodemographic, clinical, and B-mode factors as predictors of elastography stiffness using logistic regression.
Main Results:
- Invasive ductal carcinoma of no special type (IDC-NST) was the predominant subtype (84.7%).
- Grade III tumors showed significantly higher tissue stiffness than grade II tumors (p < 0.05).
- Stiff lesions were predominantly IDC-NST (83.3%); higher grade correlated with increased stiffness.
Conclusions:
- SWE findings correlate significantly with breast cancer histopathological grades and subtypes.
- SWE shows potential as a tool for predicting tumor aggressiveness and characterizing subtypes.
- SWE enhances diagnostic accuracy, complementing traditional imaging for personalized treatment.
