Analysis of the Ki-67 Proliferation Index in Relation to Tumor, Node, and Metastasis (TNM) Stage in Patients With Oral Cavity Squamous Cell Carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.The Ki-67 proliferation index in oral squamous cell carcinoma (SCC) correlates with advanced tumor stage. Higher Ki-67 levels indicate greater tumor aggressiveness and invasiveness, aiding in predicting SCC behavior.
Area Of Science
- Oncology
- Pathology
Background
- Squamous cell carcinoma (SCC) is the most common oral malignancy, particularly in South Asia.
- Current five-year survival rates for SCC remain suboptimal at approximately 50%.
- Understanding tumor biology is crucial for improving SCC patient outcomes.
Purpose Of The Study
- To analyze the Ki-67 proliferation index in oral cavity SCC.
- To correlate Ki-67 index with tumor stage, nodal stage, and tumor grade.
- To assess the biological aggressiveness of SCC.
Main Methods
- Retrospective study of 50 biopsy-proven oral cavity SCC patients (2018-2022).
- Immunohistochemistry used to determine the Ki-67 proliferation index in tumor cells.
- Statistical analysis to correlate Ki-67 index with clinicopathological parameters.
Main Results
- A higher Ki-67 index (>20%) was significantly associated with advanced T stage (T3-T4) oral SCC (p=0.047).
- No significant association was found between Ki-67 index and nodal status.
- No significant association was found between Ki-67 index and tumor grade.
Conclusions
- The Ki-67 proliferation index is a valuable biomarker for predicting the behavior of oral SCC.
- Elevated Ki-67 levels indicate increased tumor size and invasiveness.
- Ki-67 can help assess the biological aggressiveness of oral SCC lesions.
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