Related Experiment Video
Updated: Jun 18, 2025
Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
Published on: July 22, 2020
TRIM28 in cancer and cancer therapy
Kailang Li1, Haifeng Wang1, Bitao Jiang1
1Department of Oncology and Hematology, Beilun District People's Hospital, Ningbo, China.
Abstract:
TRIM28 (tripartite motif protein 28) was initially believed to be a transcription inhibitor that plays an important role in DNA damage repair (DDR) and in maintaining cancer cellular stemness. As research has continued to deepen, several studies have found that TRIM28 not only has ubiquitin E3 ligase activity to promote degradation of substrates, but also can promote SUMOylation of substrates. Although TRIM28 is highly expressed in various cancer tissues and has oncogenic effects, there are still a few studies indicating that TRIM28 has certain anticancer effects. Additionally, TRIM28 is subject to complex upstream regulation. In this review, we have elaborated on the structure and regulation of TRIM28. At the same time, highlighting the functional role of TRIM28 in tumor development and emphasizing its impact on cancer treatment provides a new direction for future clinical antitumor treatment.
Insights
Tripartite motif protein 28 (TRIM28) has dual roles in cancer, influencing DNA repair and stemness. This review explores TRIM28
Area of Science:
- Molecular Biology
- Cancer Biology
- Biochemistry
Background:
- TRIM28 (tripartite motif protein 28) initially recognized for transcription inhibition in DNA damage repair (DDR) and cancer stemness.
- Emerging evidence reveals TRIM28's dual roles: ubiquitin E3 ligase activity and SUMOylation promotion.
- TRIM28 exhibits complex upstream regulation and context-dependent functions in cancer.
Purpose of the Study:
- To review the structure and regulation of TRIM28.
- To elucidate the multifaceted functional roles of TRIM28 in tumor development.
- To highlight TRIM28's impact on cancer treatment strategies.
Main Methods:
- Literature review and synthesis of existing research on TRIM28.
- Analysis of TRIM28's molecular mechanisms, including its enzymatic activities.
- Examination of TRIM28's expression patterns and functional significance in various cancers.
Main Results:
- TRIM28 possesses both oncogenic and potential anticancer effects, depending on the cellular context.
- Its dual enzymatic activities (ubiquitination and SUMOylation) contribute to its diverse functions.
- Complex upstream regulatory networks influence TRIM28's activity and downstream effects.
Conclusions:
- TRIM28 is a key regulator in cancer, with implications for tumor progression and therapeutic intervention.
- Understanding TRIM28's complex roles offers new avenues for developing targeted cancer therapies.
- Further research into TRIM28 regulation and function is crucial for clinical applications.
More Related Videos
Related Concept Videos
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
03:03mTOR Signaling and Cancer Progression
The mTOR pathway or the...
01:12Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
02:38Mitogens and the Cell Cycle
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...