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Updated: Jun 18, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Bacillus coagulans-associated severe necrotizing scleral infection
Beau Sylvester1, Spencer D Fuller2, Laura Certain3
1Department of Ophthalmology and Visual Sciences, Washington University School of Medicine in St. Louis, St. Louis, USA.
Purpose:
We describe a case of severe scleritis possibly caused by Bacillus coagulans.
Observations:
Conventional laboratory evaluation was inconclusive. The associated organism was identified with metagenomic RNA deep sequencing (MDS). The infection resolved with trimethoprim-sulfamethoxazole treatment.
Conclusions:
This case demonstrates the utility of unbiased, high-throughput sequencing for infectious scleritis.
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