Risk factors for distant metastasis and prognosis of the penile cancer with distant metastasis
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View abstract on PubMed
Summary
This summary is machine-generated.This study identified tumor size and N stage as key predictors of distant metastasis in penile cancer (PC). Developed nomograms accurately predict metastasis and survival, aiding in managing this rare disease.
Area Of Science
- Oncology
- Urologic Oncology
- Cancer Epidemiology
Background
- Penile cancer (PC) is a rare malignancy with poor outcomes associated with distant metastasis (DM).
- Risk factors for DM and prognosis in PC patients with DM remain poorly understood.
- Identifying these factors is crucial for improving patient management and outcomes.
Purpose Of The Study
- To investigate independent risk factors associated with distant metastasis in penile cancer.
- To develop predictive models (nomograms) for distant metastasis, overall survival (OS), and cancer-specific survival (CSS) in PC patients.
Main Methods
- Analysis of 1,488 penile cancer cases from the SEER database (2000-2020).
- Utilized univariate/multivariate logistic regression and Cox regression to identify risk factors.
- Developed nomograms for predicting DM, OS, and CSS.
Main Results
- Tumor size and N stage were identified as independent predictors of DM in PC.
- The DM prediction nomogram achieved an AUC of 0.904.
- Survival rates for PC with DM were low (1-, 3-, 5-year: 35%, 17%, 13%). Advanced age, TNM stage, and chemotherapy correlated with poorer prognosis.
Conclusions
- Tumor size and N stage are significant predictors of distant metastasis in penile cancer.
- Developed nomograms provide valuable tools for predicting DM, OS, and CSS in PC patients.
- These models can aid clinicians in risk stratification and treatment planning for penile cancer.
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