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[Fundamental data in hemorheology. II. Hyperviscosity syndromes]
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1985
Summary
Hyperviscosity syndromes involve increased blood viscosity and flow resistance due to rheological changes in whole blood. These conditions stem from various factors affecting plasma proteins, blood cell counts, and cell properties.
Area of Science:
- Hematology
- Biophysics
- Rheology
Context:
- Whole blood functions as a deformable colloidal suspension within a macromolecular environment.
- Pathological alterations in blood rheology lead to clinical manifestations known as hyperviscosity syndromes.
- The concept of hyperviscosity has evolved from characterizing plasma hyperviscosity in macroglobulinemia to encompassing the rheological behavior of whole blood.
Purpose:
- To define and elaborate on the multifaceted nature of hyperviscosity syndromes.
- To explore the diverse etiologies contributing to increased blood viscosity and flow resistance.
- To underscore the importance of considering blood's rheological properties holistically.
Summary:
- Hyperviscosity syndromes are characterized by elevated blood viscosity and flow resistance.
- Etiologies include increased plasma protein levels, monoclonal proteins, elevated blood cell counts, and altered erythrocyte properties (internal viscosity, viscoelasticity, aggregation).
- Platelet aggregation may also contribute to these syndromes.
Impact:
- Provides a comprehensive understanding of hyperviscosity syndromes for clinicians and researchers.
- Highlights the complex interplay between blood composition and flow dynamics.
- Facilitates improved diagnosis and management of conditions associated with abnormal blood viscosity.