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The prokaryote-eukaryote interface.

L T Hunt, D G George, W C Barker

    Bio Systems
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Protein and nucleic acid sequence analysis provides key evidence for biological evolution. This research confirms the endosymbiotic origin of eukaryotic cells using ribosomal RNA sequence comparisons.

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    Area of Science:

    • Molecular Biology
    • Evolutionary Biology
    • Genomics

    Background:

    • The study of protein and nucleic acid sequences has yielded vast information over 30 years.
    • Technological advances, particularly in nucleic acid sequencing, have accelerated data accumulation.
    • Sequence data is crucial for understanding evolutionary relationships and genetic mechanisms.

    Purpose of the Study:

    • To elucidate relationships among the genomes of living organisms.
    • To deduce phylogenetic history.
    • To resolve the origin of eukaryotic cells by testing competing hypotheses.

    Main Methods:

    • Comparison of protein and nucleic acid sequences.
    • Analysis of small subunit ribosomal RNAs (rRNAs).
    • Construction of evolutionary trees.

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    Main Results:

    • Sequence data provided strong evidence for biological evolution.
    • Comparisons of small subunit ribosomal RNAs supported the endosymbiotic origin of eukaryotic cells.
    • The study resolved a long-standing controversy regarding eukaryotic cell origins.

    Conclusions:

    • Protein and nucleic acid sequence analysis is a powerful tool for evolutionary studies.
    • The endosymbiotic theory for the origin of eukaryotic cells is strongly supported by molecular sequence data.
    • Further research can utilize these methods to explore phylogenetic history.