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Engineering a Bilayered Hydrogel to Control ASC Differentiation

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Human Chorionic Membrane-derived Tunable Hydrogels for Vascular Tissue Engineering Strategies.

Elisa A G Martins¹, Inês A Deus¹, Maria C Gomes¹

¹Department of Chemistry, CICECO, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.

Advanced Healthcare Materials

|August 5, 2024

Summary

Researchers developed a novel biomaterial from decellularized human placenta (CM) for tissue engineering. This methacrylated CM (CMMA) hydrogel supports vascular network formation, crucial for thicker tissue development.

Keywords:

angio‐vasculogenic properties decellularized extracellular matrix human chorionic membrane photopolymerizable hydrogels placenta

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Last Updated: Jun 21, 2026

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Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

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Tunable Hydrogels from Pulmonary Extracellular Matrix for 3D Cell Culture

Tunable Hydrogels from Pulmonary Extracellular Matrix for 3D Cell Culture

Published on: January 17, 2017

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Engineering vascularized tissues requires biomaterials that mimic native tissue composition and support vascular network formation.
Current biomaterials often lack the mechanical robustness and angiogenic potential needed for complex tissue constructs.
The placenta chorionic membrane (CM) is a rich source of extracellular matrix components, often considered medical waste.

Purpose of the Study:

To develop a clinically relevant biomaterial from human decellularized extracellular matrix for vascularized tissue engineering.
To create a robust and angiogenic hydrogel capable of supporting endothelial cell organization into vascular structures.
To repurpose placental chorionic membrane (CM) into a valuable bioengineering resource.

Main Methods:

Decellularization of human placenta chorionic membrane (CM).
Chemical modification of decellularized CM with methacryloyl groups to create methacrylated CM (CMMA).
Characterization of CMMA hydrogel mechanical properties, protein/glycosaminoglycan content, and photopolymerization capabilities.
In vitro and in vivo assessment of CMMA's angio-vasculogenic potential using endothelial cells.

Main Results:

Methacrylated CM (CMMA) hydrogels exhibit robust mechanical properties in the kPa range.
CMMA hydrogels support the self-assembly of human umbilical vein endothelial cells into stable tubular structures for 14 days in vitro.
The biomaterial preserves key extracellular matrix proteins and glycosaminoglycans.
CMMA demonstrates significant angio-vasculogenic competence both in vitro and in vivo.

Conclusions:

Methacrylated CM (CMMA) hydrogels represent a novel, clinically relevant biomaterial for vascularized tissue engineering.
This humanized platform effectively supports endothelial cell organization and vascular network formation.
Repurposing placental CM provides a sustainable and promising approach for developing advanced biomaterials.