The association between HbA1c/C-peptide levels and short-term mortality in patients diagnosed with myocardial...

Area of Science:

• Cardiology
• Endocrinology
• Clinical Medicine

Background:

• Myocardial infarction (MI) poses a significant risk for short-term mortality.
• Early identification of patients at high risk of mortality post-MI is crucial for timely intervention.
• The predictive value of the HbA1C/C-peptide ratio (HCR) in MI patients requires further investigation.

Purpose of the Study:

• To investigate the efficacy of the HbA1C/C-peptide ratio (HCR) score in predicting 30-day mortality following myocardial infarction.
• To evaluate the HCR score's predictive performance in patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI).

Main Methods:

• A cohort of 3245 patients admitted with STEMI or NSTEMI between October 2020 and 2024 were analyzed.
• All patients underwent primary percutaneous coronary intervention.
• Receiver operating characteristic (ROC) analysis was employed to assess the predictive power of the HCR score.

Main Results:

• The HCR score demonstrated 83% sensitivity and 81% specificity for predicting mortality in STEMI patients.
• For NSTEMI patients, the HCR score showed 78% sensitivity and 75% specificity in predicting mortality.
• These findings highlight the HCR score's significant predictive capability across different MI types.

Conclusions:

• The HbA1C/C-peptide ratio score serves as a valuable tool for early prediction of poor clinical outcomes in myocardial infarction.
• Utilizing the HCR score can aid in reducing mortality and morbidity rates in MI patients.
• This ratio offers a promising biomarker for risk stratification and management of cardiovascular disease.