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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
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Morphologic Spectrum of HPV-associated Sinonasal Carcinomas
Tarek Abi-Saab1, Taja Lozar2, Yi Chen3
1Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Head and Neck Pathology
|August 5, 2024
Summary
High-risk human papillomavirus (HR-HPV) is linked to sinonasal carcinomas, including a newly identified adenocarcinoma subtype. Routine testing is recommended to understand HPV-associated sinonasal cancer behavior.
Area of Science:
- Oncology
- Pathology
- Virology
Background:
- High-risk human papillomavirus (HR-HPV) infection is an emerging risk factor for sinonasal tract carcinomas.
- Limited studies and inconsistent HPV testing methods hinder understanding of HPV-associated sinonasal carcinomas.
- HPV-associated sinonasal carcinomas exhibit diverse morphology, with HPV-associated adenocarcinoma previously unreported.
Purpose of the Study:
- To determine the prevalence of HPV-associated sinonasal carcinomas.
- To investigate the morphologic spectrum of these tumors.
- To assess the prognostic implications of HPV in sinonasal carcinomas.
Main Methods:
- A cohort of 153 sinonasal carcinomas was analyzed.
- Tissue microarrays were used for p16 immunohistochemistry and HR-HPV E6/7 in-situ Hybridization (ISH).
- HPV-association was confirmed by positive ISH results, with clinicopathologic data collected.
Main Results:
- 18% (28/153) of sinonasal carcinomas were HPV-associated.
- These included squamous cell carcinomas (93%), HPV-related multiphenotypic carcinoma (3.5%), and a novel adenocarcinoma subtype (3.5%).
- A trend towards improved survival was observed in HPV-associated cases, though not statistically significant.
Conclusions:
- A novel HPV-associated sinonasal adenocarcinoma subtype was identified.
- The study highlights the diverse morphology of HPV-associated sinonasal carcinomas.
- Routine p16 and HR-HPV testing is recommended for all sinonasal carcinoma subtypes to aid clinical behavior studies.
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