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Related Concept Videos

iChip01:24

iChip

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The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
79

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Related Experiment Video

Updated: Apr 15, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

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Standard: human intestine-on-a-chip.

Haitao Liu1, Yaqing Wang2,3, Xu Zhang1

  • 1Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

Cell Regeneration (London, England)
|August 5, 2024
PubMed
Summary
This summary is machine-generated.

China has released the first group standard for human intestine-on-a-chip, addressing a critical need for standardization in organs-on-chips technology. This standard aims to accelerate the development and application of these advanced models in life sciences.

Keywords:
Intestine-on-a-chipMicrophysiological systemOrgans-on-chipsStandard

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Area of Science:

  • Biotechnology and Life Sciences
  • Microphysiological Systems
  • Organoid Technology

Background:

  • Organs-on-chips (OOCs) are advanced microphysiological systems that mimic human organ functions, crucial for disease modeling, drug development, and precision medicine.
  • Current OOC applications are hindered by a lack of standardized definitions, structural designs, cell sources, construction methods, and validation protocols.
  • The development of standardized protocols is essential for the broad translational application of OOC technology.

Discussion:

  • The newly released "Organs-on-chips: Intestine" group standard in China establishes clear guidelines for human intestine-on-a-chip models.
  • This standard covers essential aspects including scope, terminology, technical requirements, detection methods, and quality control for constructing reliable intestinal OOCs.
  • Its publication by the Chinese Society of Biotechnology signifies a major step towards consistent and reproducible OOC development.

Key Insights:

  • This standard is the first of its kind in China specifically for human intestine-on-a-chip models.
  • It provides a framework for establishing, validating, and implementing intestine-on-a-chip protocols in research and development.
  • The standard is expected to enhance the reliability and comparability of intestine-on-a-chip research globally.

Outlook:

  • The standard is anticipated to guide institutional adoption and execution of best practices for intestine-on-a-chip development.
  • It will play a pivotal role in accelerating the international standardization of intestine-on-a-chip technology.
  • This initiative is poised to significantly advance the translational applications of OOCs in areas like drug discovery and personalized medicine.