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Neuroplasticity in Parkinson's disease
Bogdan Ovidiu Popescu1,2, Lucia Batzu3,4, Pedro J Garcia Ruiz5
1Department of Clinical Neurosciences, 'Carol Davila' University of Medicine and Pharmacy Bucharest, Bucharest, Romania. bogdan.popescu@umfcd.ro.
Journal of Neural Transmission (Vienna, Austria : 1996)
|August 5, 2024
Summary
Parkinson's disease (PD) involves brain changes at multiple levels. This review explores neuroplasticity in PD, examining beneficial and maladaptive responses to treatments and disease progression.
Area of Science:
- Neuroscience
- Neurology
- Neurodegeneration
Background:
- Parkinson's disease (PD) is a prevalent neurodegenerative disorder with increasing incidence.
- While no cure exists, effective treatments are available for PD, even in advanced stages.
- Neuroplasticity, the brain's adaptive capacity, is crucial for understanding PD pathology and treatment responses.
Purpose of the Study:
- To review current knowledge on neuroplasticity in Parkinson's disease.
- To examine neuroplastic changes at network, cellular, and molecular levels in PD.
- To analyze both beneficial and detrimental neuroplastic responses in PD.
Main Methods:
- Literature review of neuroplasticity in Parkinson's disease.
- Analysis of neuroplasticity at network, cellular, and molecular levels.
- Examination of adaptive and maladaptive neuroplasticity, including treatment effects.
Main Results:
- Neuroplasticity in PD involves complex network, cellular, and molecular adaptations.
- Beneficial neuroplastic effects include enhanced neuronal efficacy.
- Maladaptive neuroplasticity, such as levodopa-induced dyskinesia, can occur.
Conclusions:
- Understanding neuroplasticity is key to managing Parkinson's disease.
- Physical activity and treatments can modulate neuroplasticity in PD.
- Biomarker identification for neuroplasticity holds therapeutic potential.
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