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Characterizing dispersion in bovine liver using ARFI-based shear wave rheometry.
Sanjay S Yengul1, Paul E Barbone1, Bruno Madore2
1Department of Mechanical Engineering, Boston University, Boston, MA, 02215, United States of America.
Biomedical Physics & Engineering Express
|August 5, 2024
Summary
Shear Wave Rheometry (SWR) accurately models shear properties in bovine liver across a wide frequency range, validating its core assumptions for tissue analysis.
Area of Science:
- Biomedical Engineering
- Rheology
- Medical Imaging
Background:
- Dispersion in shear wave elastography (SWE) presents challenges and diagnostic opportunities.
- Shear Wave Rheometry (SWR) processes acoustic radiation force impulse (ARFI) data to characterize soft media.
- SWR assumes tissue homogeneity, isotropy, and axisymmetric excitation.
Purpose of the Study:
- To assess the validity of SWR assumptions in ex vivo bovine liver.
- To evaluate SWR's performance across a broad frequency spectrum.
Main Methods:
- SWR was applied to measure shear properties of bovine liver.
- Measurements were taken at various locations and probe orientations to test assumptions.
- Quantities revealing assumption violations were specifically measured.
Main Results:
- Shear properties were measured from 25-250 Hz.
- Shear storage modulus increased fourfold (1-4 kPa), and loss modulus increased tenfold (0.2-3 kPa).
- Measurements demonstrated high repeatability with low model error.
Conclusions:
- The simplifying assumptions of SWR are valid for bovine liver.
- SWR accurately models ARFI-induced shear waves as vector viscoelastic waves.
- SWR is a versatile tool for characterizing soft tissue rheology.
