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Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
Published on: February 3, 2022
Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune
Bobin Mi1,2, Yuan Xiong1,2, Samuel Knoedler3,4
1Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
Abstract:
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including the skeletal and immune systems. Recent studies have elucidated the intricate bidirectional interactions between these two systems. In this review, we provide a comprehensive synthesis of molecular mechanisms of cell ageing. We further discuss how age-related skeletal changes influence the immune system and the consequent impact of immune system alterations on the skeletal system. Finally, we highlight the clinical implications of these findings and propose potential strategies to promote healthy ageing and reduce pathologic deterioration of both the skeletal and immune systems.
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