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PARP1-dependent DNA-protein crosslink repair

Zita Fábián1, Ellen S Kakulidis1,2, Ivo A Hendriks1

  • 1The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.

Nature Communications
|August 5, 2024
PubMed
Summary

Poly(ADP-ribosyl)ation (PARylation) repairs toxic DNA-protein crosslinks (DPCs) via PARP1. This pathway is crucial for resolving topoisomerase 1-DNA cleavage complexes (TOP1ccs), preventing replication fork collapse.

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