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Cord blood vitamin E and lipids in infants born small for gestational age

Guicun Yang1,2, Nianrong Wang1,2, Hao Liu1,2

  • 1Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China.

European Journal of Pediatrics
|August 5, 2024
PubMed

Insights

High vitamin E in cord blood may increase the risk of infants being small for gestational age (SGA). This study found elevated vitamin E and lipids in SGA infants, suggesting a role in fetal growth and lipid metabolism.

Area of Science:

  • Perinatal Medicine
  • Nutritional Biochemistry

Background:

  • Vitamin E plays a role in regulating lipid metabolism.
  • Vitamin E levels are inversely related to birth weight.
  • Previous research suggests a link between vitamin E and fetal growth.

Purpose of the Study:

  • To investigate the association between vitamin E, fetal growth, and lipid profiles.
  • To determine if cord blood vitamin E levels correlate with small for gestational age (SGA) status.
  • To explore the relationship between vitamin E and lipid concentrations in newborns.

Main Methods:

  • Analysis of cord plasma from 146 mother-infant pairs.
  • Measurement of vitamin E and lipid concentrations in cord blood.
  • Statistical analysis to assess associations and risks, including odds ratios (OR) and confidence intervals (CI).

Main Results:

  • Elevated cord plasma vitamin E levels were observed in infants who were small for gestational age (SGA).
  • Higher vitamin E concentrations were associated with an increased risk of SGA (OR = 2.239).
  • A positive correlation was found between cord blood vitamin E and lipid levels.

Conclusions:

  • Elevated cord blood vitamin E may be linked to a higher risk of SGA.
  • Vitamin E concentrations are positively correlated with lipid levels in newborns.
  • These findings suggest a potential role for vitamin E in fetal lipid metabolism and growth.

Keywords:
LipidSmall for gestational ageUmbilical cord bloodVitamin E

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