Related Experiment Video
Updated: Jun 17, 2025

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
Association between high birth weight and dental caries at 4-5 years of age: a birth-cohort study
Huning Wang1,2, Hao Zhang1,2, Xiaoli Zeng1,2
1Department of Preventive Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China.
Insights
High birth weight is a significant risk factor for early childhood caries. Children born weighing 4,000 grams or more have an increased incidence and severity of dental caries.
Area of Science:
- Pediatric Dentistry
- Public Health
- Neonatal Research
Background:
- Early childhood caries (ECC) is a major global oral health concern.
- While low birth weight's link to ECC is studied, high birth weight's impact remains less explored.
Purpose of the Study:
- To investigate the association between high birth weight and the incidence and severity of dental caries in young children.
- To identify high birth weight as a potential risk factor for ECC.
Main Methods:
- A birth cohort study analyzed 491 children aged 4-5 years.
- Dental caries, prenatal/perinatal factors, and socio-demographic data were collected.
- Logistic regression models adjusted for confounders were used.
Main Results:
- 48.7% of children had dental caries.
- High birth weight (≥4,000g) was significantly associated with increased caries incidence (OR 2.000).
- The risk of severe caries (dmft ≥3) was higher in high birth weight infants (OR 2.437).
Conclusions:
- High birth weight is identified as a risk factor for early childhood caries.
- Children with birth weights of 4,000g or more require focused dental monitoring.
- This finding highlights the importance of considering birth weight in ECC prevention strategies.
Objective:
Early childhood caries has become a globally crucial oral health problem over the decades. Most studies have discussed the association between low birth weight and early childhood caries; however, studies focusing on high birth weight have been relatively limited. This study aimed to assess the impact of high birth weight on the incidence and severity of dental caries in 4-5-year-old children.
Subjects And Methods:
Study subjects included 491 children from a birth cohort study at 4-5 years of age. Data on dental caries, prenatal and perinatal factors, and socio-demographic determinants were recorded. Logistic regression models adjusted for potential confounders were performed to analyze the data. Two-sided P-value < 0.05 was considered statistically significant.
Results:
Of the 491 children, the prevalence of dental caries was 48.7%. High birth weight (≥ 4,000 g) was significantly associated with increased incidence of dental caries (OR, 2.000; CI 95% 1.062-3.765), and the relatively enhanced risk OR was further increased in subjects experiencing caries (dmft ≥ 3) (OR, 2.437; CI 95% 1.306-4.549) compared with the normal birth weight (2,500-3,999 g).
Conclusions:
High birth weight is a risk factor for early childhood caries. Particular attention should be paid to children with birth weight more than or equal to 4,000 g.
Related Concept Videos
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
Psychosexual Stages of Personality: Oral
Weaning, typically occurring...
Oral Cavity
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...

