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Ceftriaxone: a third-generation cephalosporin.

M C Nahata, W J Barson

    Drug Intelligence & Clinical Pharmacy
    |December 1, 1985
    PubMed
    Summary
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    Ceftriaxone, a third-generation cephalosporin, shows broad-spectrum efficacy and safety for various infections. Its convenient dosing offers potential cost savings, making it a preferred treatment option.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Clinical Microbiology

    Background:

    • Ceftriaxone is a novel third-generation cephalosporin antibiotic.
    • It exhibits significant activity against Gram-negative and moderate activity against Gram-positive bacteria.

    Purpose of the Study:

    • To evaluate the efficacy and safety of ceftriaxone in treating various bacterial infections.
    • To assess the clinical utility of ceftriaxone based on its pharmacokinetic profile and dosing schedule.

    Main Methods:

    • Clinical studies were conducted to assess ceftriaxone's effectiveness.
    • Safety and tolerability were monitored, including adverse events like diarrhea.
    • Pharmacokinetic properties, specifically elimination half-life, were analyzed.

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    Main Results:

    • Ceftriaxone demonstrated efficacy in treating bacterial meningitis, respiratory, urinary tract, soft tissue, bone and joint infections, and gonorrhea.
    • The drug was generally well-tolerated, with diarrhea being the most common side effect, usually not requiring therapy change.
    • A long elimination half-life permits twice-daily or once-daily dosing.

    Conclusions:

    • Ceftriaxone is an effective and safe antibiotic for numerous serious bacterial infections.
    • The convenient dosing schedule, including once-daily administration, may lead to cost savings.
    • Ceftriaxone is a potential preferred choice among third-generation cephalosporins for treating serious infections.