Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

10.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
Blood Transfusion01:15

Blood Transfusion

532
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
532
Blood Typing01:10

Blood Typing

1.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K
Blood Types02:20

Blood Types

17.5K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.5K
Rh Blood Group01:19

Rh Blood Group

1.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

317
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
317

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification and structural analysis of a novel FUT1 c.789C>A variant and previously reported para-Bombay alleles using an α2FucT1 structural model.

Transfusion·2026
Same author

New RHCE*cE allele with c.872C>G and variable RH3 and RH4 phenotypes, predicted to encode p.Pro291Arg.

Transfusion·2026
Same author

Novel RHCE*cE(341A) allele.

Transfusion·2026
Same author

A novel JK-null allele due to splicing variant.

Transfusion·2026
Same author

Identification of the novel c.149-8C>G splicing variant in RHCE*02 that weakens C antigen expression.

Transfusion·2026
Same author

A novel RHCE*cE689C allele (p.Ser230Thr) in 2 donors of European ancestry with discrepant E antigen typing.

Transfusion·2026

Related Experiment Video

Updated: Jun 17, 2025

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.1K

Blood group genotype matching for transfusion.

Connie M Westhoff1, Aline Floch2,3

  • 1New York Blood Center Enterprises, National Center for Blood Group Genomics, New York, New York, USA.

British Journal of Haematology
|August 6, 2024
PubMed
Summary

DNA genotyping advances blood group antigen typing for complex transfusions and patient care. Standardizing these genetic testing methods is crucial for broader clinical adoption and improved outcomes.

Keywords:
A2 genotypingantigen‐matchingblood group genotypingblood groupsextended antigen typinggenotypingnon‐A1 genotype

More Related Videos

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.3K
A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
07:27

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

18.7K

Related Experiment Videos

Last Updated: Jun 17, 2025

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.1K
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.3K
A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
07:27

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

18.7K

Area of Science:

  • Genetics
  • Immunology
  • Clinical Medicine

Background:

  • DNA-based methods for extended antigen typing and gene sequencing have grown significantly over the last decade.
  • Blood group gene variation analysis is increasingly used to guide clinical care.
  • Challenges remain in professional education, accessibility, and standardization of genotyping for routine patient care.

Purpose of the Study:

  • To discuss the applications of genotyping in complex transfusion scenarios.
  • To highlight the role of genetic testing in managing allo- and auto-antibodies in transplantation.
  • To review current and emerging genotyping technologies.

Main Methods:

  • Discussion of applications including difficult transfusions, unclear Rh types, and antibody issues in transplantation.
  • Review of prenatal testing for maternal and fetal risk assessment.
  • Summary of Group A subtyping for organ and platelet donors.
  • Overview of commercial testing resources and novel approaches like high-density arrays and targeted next-generation sequencing (NGS).

Main Results:

  • Genotyping offers solutions for transfusion incompatibilities not resolved by routine methods.
  • It is vital for managing complex immunological challenges in transplantation and prenatal diagnostics.
  • Advanced techniques like NGS are expanding testing capabilities.

Conclusions:

  • Genotyping is essential for managing complex transfusion needs and improving patient outcomes.
  • Wider adoption requires addressing education, accessibility, and standardization.
  • Emerging technologies promise further advancements in blood group genetics and clinical applications.