Jove
Visualize
Contact Us

Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

972
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
972

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging Filamentous Basidiomycetes as Opportunistic Human Pathogens: Diagnostic and Antifungal Challenges in a Tertiary-Care Center in Thailand.

Antibiotics (Basel, Switzerland)·2026
Same author

ALK-positive, EBV-positive Large B-cell lymphoma in an HIV patient: a diagnostic pitfall mimicking plasmablastic lymphoma.

Journal of hematopathology·2026
Same author

Clinical characteristics and outcomes of myeloid neoplasms with <i>MECOM</i> rearrangements.

Journal of clinical pathology·2025
Same author

Clinical and Genomic Insights into Antifungal Resistance in <i>Aspergillus</i> Isolates from Thailand.

Microorganisms·2025
Same author

Optimizing Markers for Chronic Lymphocytic Leukemia Diagnosis by Flow Cytometry: Results From the Nationwide Thai Lymphoma Study Group.

Journal of clinical laboratory analysis·2025
Same author

Comparative efficacy and safety of BCMA-targeted CAR T cells and BiTEs in relapsed/refractory multiple myeloma: a meta-analysis of interventional and real-world studies.

Annals of hematology·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 17, 2025

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues
07:17

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

1.0K

T-PLL Presenting with an Indolent Course.

Arsa Thammahong1,2, Narittee Sukswai3, Chantana Polprasert1,4

  • 1Department of Medicine Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Case Reports in Hematology
|August 6, 2024
PubMed
Summary
This summary is machine-generated.

This case study details an asymptomatic patient diagnosed with T-cell prolymphocytic leukemia (T-PLL). The diagnosis was confirmed through clinical findings, cell morphology, and flow cytometry, revealing an abnormal CD4+ T-cell population.

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.1K
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

21.1K

Related Experiment Videos

Last Updated: Jun 17, 2025

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues
07:17

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

1.0K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.1K
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

21.1K

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • T-cell prolymphocytic leukemia (T-PLL) is a rare and typically aggressive mature T-cell leukemia.
  • Diagnosis often relies on a combination of clinical presentation, blood morphology, and immunophenotyping.

Observation:

  • An asymptomatic patient presented with incidental lymphocytosis and lymphadenopathy.
  • Flow cytometry identified an expanded CD4+ T-cell population in peripheral blood.
  • Next-generation sequencing confirmed T-cell receptor clonality, indicating a dominant clone.

Findings:

  • No pathogenic mutations were detected in a panel of 25 lymphoma-related genes.
  • The patient remained asymptomatic despite the T-PLL diagnosis.
  • A conservative monitoring approach was adopted, involving regular clinical and blood count assessments.

Implications:

  • This case highlights the possibility of asymptomatic T-PLL presentation.
  • It underscores the utility of flow cytometry and T-cell receptor clonality in diagnosing T-PLL.
  • The findings support a watchful waiting strategy for select asymptomatic T-PLL patients.