Legumain in cardiovascular diseases

Area of Science:

• Biochemistry
• Cardiology
• Enzymology

Background:

• Cardiovascular diseases (CVDs) are a major global health concern and leading cause of mortality worldwide.
• Further research into the pathophysiological mechanisms and therapeutic strategies for CVDs is crucial.
• Legumain, a widely distributed mammalian enzyme, is implicated in various biological processes.

Purpose of the Study:

• To provide a comprehensive review of legumain's role in the pathogenesis of cardiovascular diseases.
• To discuss the involvement of legumain in specific CVDs, including atherosclerosis and hypertension.
• To explore the potential of legumain as a diagnostic biomarker for cardiovascular conditions.

Main Methods:

• Literature review of existing research on legumain and cardiovascular diseases.
• Analysis of studies investigating legumain's function in different cardiovascular conditions.
• Synthesis of findings on legumain's involvement in disease occurrence and progression.

Main Results:

• Legumain is associated with the occurrence and progression of various cardiovascular diseases.
• The enzyme plays a significant role in conditions such as carotid atherosclerosis, pulmonary hypertension, coronary artery disease, peripheral arterial disease, and aortic aneurysms/dissection.
• Legumain shows potential as a biomarker for these cardiovascular diseases.

Conclusions:

• Understanding legumain's role in CVD pathogenesis is essential for developing novel therapeutic strategies.
• Targeting legumain may offer new avenues for preventing or treating cardiovascular diseases.
• Further investigation into legumain's mechanisms could lead to improved diagnostic and therapeutic approaches for CVDs.