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Related Experiment Video

Updated: Jun 17, 2025

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Legumain in cardiovascular diseases.

Lei Zhou^1,2, Jianqiang Wu³, Zairong Wei¹

¹Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Experimental Biology and Medicine (Maywood, N.J.)

|August 6, 2024

Summary

Legumain enzyme plays a key role in cardiovascular diseases (CVDs) development and progression. Understanding legumain

Keywords:

aortic disease atherosclerosis cardiovascular disease coronary artery disease legumain

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Published on: June 21, 2016

Area of Science:

Biochemistry
Cardiology
Enzymology

Background:

Cardiovascular diseases (CVDs) are a major global health concern and leading cause of mortality worldwide.
Further research into the pathophysiological mechanisms and therapeutic strategies for CVDs is crucial.
Legumain, a widely distributed mammalian enzyme, is implicated in various biological processes.

Purpose of the Study:

To provide a comprehensive review of legumain's role in the pathogenesis of cardiovascular diseases.
To discuss the involvement of legumain in specific CVDs, including atherosclerosis and hypertension.
To explore the potential of legumain as a diagnostic biomarker for cardiovascular conditions.

Main Methods:

Literature review of existing research on legumain and cardiovascular diseases.
Analysis of studies investigating legumain's function in different cardiovascular conditions.
Synthesis of findings on legumain's involvement in disease occurrence and progression.

Main Results:

Legumain is associated with the occurrence and progression of various cardiovascular diseases.
The enzyme plays a significant role in conditions such as carotid atherosclerosis, pulmonary hypertension, coronary artery disease, peripheral arterial disease, and aortic aneurysms/dissection.
Legumain shows potential as a biomarker for these cardiovascular diseases.

Conclusions:

Understanding legumain's role in CVD pathogenesis is essential for developing novel therapeutic strategies.
Targeting legumain may offer new avenues for preventing or treating cardiovascular diseases.
Further investigation into legumain's mechanisms could lead to improved diagnostic and therapeutic approaches for CVDs.