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Malignant Phyllodes Tumor With Chondroblastic Osteosarcomatous Differentiation: A Case Report
Matthew Carpenter1, Shahla Masood2, Swati Sharma3
1Pathology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Abstract:
Malignant phyllodes tumors (MPTs) represent the most pernicious type of intralobular stromal proliferation known as a "fibroepithelial lesion" (FEL). They comprise a small fraction of breast malignancies and can present as either a pure MPT or sometimes include a heterologous component (liposarcoma, chondrosarcoma, osteosarcoma, or rhabdomyosarcoma). Of the fraction of MPTs that include heterologous components, very little about those with chondroblastic osteosarcomatous differentiation has been described in the literature. As such, a characteristic staining profile has yet to be established, even though morphological analysis is the cornerstone of diagnosis. The few reported cases have described a poor prognosis. Therefore, we present a case of MPT with chondroblastic osteosarcomatous differentiation to contribute to the dearth of literature examining this entity.
Insights
Malignant phyllodes tumors (MPTs) with chondroblastic osteosarcomatous differentiation are rare breast cancers. This case report aims to add to the limited literature on this aggressive tumor subtype.
Area of Science:
- Oncology
- Pathology
- Breast Cancer Research
Background:
- Malignant phyllodes tumors (MPTs) are rare fibroepithelial lesions of the breast.
- MPTs can exhibit heterologous differentiation, including chondroblastic osteosarcoma.
- Cases of MPTs with chondroblastic osteosarcomatous differentiation are exceptionally rare in the literature.
