Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

150
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
150
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

201
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
201
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

126
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
126

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GJ Express: an improvement initiative to decrease sedation and anesthesia for gastrojejunostomy tube exchanges.

Pediatric research·2024
Same author

A personalized medicine approach to optimize care for a pediatric cystic fibrosis patient with atypical clinical symptoms.

Pediatric pulmonology·2023
Same author

Pediatric formulas: Categories, composition, and considerations.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2023
Same author

Changes in Glucose Breath Test in Cystic Fibrosis Patients Treated With 1 Month of Lumacaftor/Ivacaftor.

Journal of pediatric gastroenterology and nutrition·2022
Same author

Overweight and cystic fibrosis: An unexpected challenge.

Pediatric pulmonology·2021
Same author

Variations in Nutrition Practices in Cystic Fibrosis: A Survey of the DIGEST Program.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2020

Related Experiment Video

Updated: Jun 17, 2025

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
07:04

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Published on: February 11, 2017

19.2K

Improving growth in infants with CF.

Megan E Gabel1,2, Rachel E Gaudio3, Ala K Shaikhkhalil4,5

  • 1University of Rochester Medical Center, University of Rochester, Rochester, New York, USA.

Pediatric Pulmonology
|August 6, 2024
PubMed
Summary
This summary is machine-generated.

Cystic fibrosis (CF) infants face growth challenges from birth, impacting health outcomes. Early nutritional support and interdisciplinary care are crucial for improving growth and survival in children with CF.

Keywords:
cystic fibrosisgrowthinfantmalnutritionnutrition

More Related Videos

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
08:00

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

10.7K
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

19.4K

Related Experiment Videos

Last Updated: Jun 17, 2025

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
07:04

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Published on: February 11, 2017

19.2K
Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
08:00

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

10.7K
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

19.4K

Area of Science:

  • Pediatric Nutrition
  • Gastroenterology
  • Pulmonology

Background:

  • Cystic fibrosis (CF) is a genetic disorder causing chronic pulmonary and gastrointestinal issues.
  • Malnutrition and poor growth are significant complications of CF, correlating with adverse clinical outcomes.
  • Early diagnosis via newborn screening enables prompt nutritional intervention and clinical management.

Purpose of the Study:

  • To highlight the critical importance of optimizing growth in infants diagnosed with cystic fibrosis.
  • To underscore the challenges and priorities in managing infant growth in CF care.
  • To emphasize the need for a comprehensive, interdisciplinary approach to CF infant management.

Main Methods:

  • Review of current understanding of growth obstacles in infants with CF.
  • Emphasis on the role of early nutritional counseling and clinical follow-up.
  • Highlighting the necessity of integrated care involving registered dietitians and social work.

Main Results:

  • Infants with CF often experience intrauterine growth restriction and lower birth weights.
  • Improved infant growth in CF is demonstrably linked to better clinical outcomes and survival rates.
  • Despite advances, challenges in linear growth, nutrition biomarkers, and health inequities persist.

Conclusions:

  • Optimizing growth is a paramount concern for infants with cystic fibrosis.
  • An interdisciplinary team approach is essential for addressing the complex nutritional and health needs of CF infants.
  • Overcoming barriers like social determinants of health is vital for global CF communities.