Quantitative non-contrast perfusion MRI in the body using arterial spin labeling

Area of Science:

• Magnetic Resonance Imaging (MRI)
• Medical Imaging Physics

Background:

• Arterial spin labeling (ASL) is a non-invasive MRI technique.
• It quantifies tissue perfusion without exogenous contrast agents.
• Originally developed for cerebral blood flow, ASL's utility has expanded to multiple organ systems.

Purpose of the Study:

• To provide a synopsis of ASL for quantitative non-contrast perfusion MRI.
• To review ASL principles, labeling strategies, and technical challenges in body imaging.
• To summarize clinical applications and future directions for ASL in body imaging.

Main Methods:

• Review of ASL principles and various labeling strategies (pulsed, continuous, pseudo-continuous, velocity-selective).
• Discussion of technical challenges in body imaging and innovative solutions.
• Summary of ASL applications in quantifying perfusion in thoracic, abdominal, and pelvic organs.

Main Results:

• ASL offers quantitative perfusion assessment without contrast agents.
• Various ASL techniques exist, each with roles in perfusion quantification.
• Technical challenges in body imaging are being addressed with innovative approaches.

Conclusions:

• ASL is a valuable tool for quantitative non-contrast perfusion MRI.
• Its application is expanding to various organs, offering insights into physiological and pathological states.
• Further development is needed for successful translation of quantitative ASL in body imaging.