Related Experiment Video
Updated: Jun 17, 2025

Author Spotlight: Advancing Varicocele Treatment with Neuromuscular Electrical Stimulation
Published on: August 30, 2024
From pathophysiology to practice: addressing oxidative stress and sperm DNA fragmentation in Varicocele-affected
Filipe Tenório Lira1,2,3, Lucas Ribeiro Campos4, Matheus Roque5
1Andros Recife, Recife, PE, Brasil.
Abstract:
Varicocele can reduce male fertility potential through various oxidative stress mechanisms. Excessive production of reactive oxygen species may overwhelm the sperm's defenses against oxidative stress, damaging the sperm chromatin. Sperm DNA fragmentation, in the form of DNA strand breaks, is recognized as a consequence of the oxidative stress cascade and is commonly found in the ejaculates of men with varicocele and fertility issues. This paper reviews the current knowledge regarding the association between varicocele, oxidative stress, sperm DNA fragmentation, and male infertility, and examines the role of varicocele repair in alleviating oxidative-sperm DNA fragmentation in these patients. Additionally, we highlight areas for further research to address knowledge gaps relevant to clinical practice.
Related Concept Videos
Infertility in Males
Spermatogenesis
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Sperm Structure and Semen Composition

