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An in-depth analysis of COVID-19 treatment: Present situation and prospects
Md Ariful Islam1, Kalyani Pathak1, Riya Saikia1
1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India.
Insights
This review summarizes current and future COVID-19 therapies, including antivirals and monoclonal antibodies. It examines clinical evidence, challenges, and ongoing research for effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) treatments.
Area of Science:
- Infectious Diseases
- Virology
- Pharmacology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, resulted in a global pandemic with significant morbidity and mortality.
- The healthcare system faced unprecedented strain due to the rapid spread and severity of COVID-19.
Purpose of the Study:
- To provide a comprehensive overview of current and emerging therapies for COVID-19.
- To summarize the clinical evidence, challenges, and future directions for COVID-19 treatment strategies.
Main Methods:
- Review of repurposed and newly developed therapeutic classes including antivirals, immunomodulators, and monoclonal antibodies.
- Analysis of clinical evidence from observational studies and randomized controlled trials.
- Examination of ongoing clinical trials and novel therapeutic candidates, including combination therapies.
Main Results:
- Multiple treatment modalities have been explored and implemented for COVID-19.
- Clinical evidence for existing therapies varies, with documented limitations and challenges.
- Ongoing research is exploring novel drug candidates and combination treatments for improved efficacy.
Conclusions:
- Effective management of COVID-19 requires a multifaceted approach incorporating diverse therapeutic strategies.
- Continued research is crucial for developing robust and sustainable treatments against SARS-CoV-2.
- Understanding long-term COVID-19 consequences and treatment efficacy is vital for public health policy and clinical practice.
Abstract:
Coronavirus disease 2019 (COVID-19) the most contagious infection caused by the unique type of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), produced a global pandemic that wreaked havoc on the health-care system, resulting in high morbidity and mortality. Several methods were implemented to tackle the virus, including the repurposing of existing medications and the development of vaccinations. The purpose of this article is to provide a complete summary of the current state and future possibilities for COVID-19 therapies. We describe the many treatment classes, such as antivirals, immunomodulators, and monoclonal antibodies, that have been repurposed or developed to treat COVID-19. We also looked at the clinical evidence for these treatments, including findings from observational studies and randomized-controlled clinical trials, and highlighted the problems and limitations of the available evidence. Furthermore, we reviewed existing clinical trials and prospective COVID-19 therapeutic options, such as novel medication candidates and combination therapies. Finally, we discussed the long-term consequences of COVID-19 and the importance of ongoing research into the development of viable treatments. This review will help physicians, researchers, and policymakers to understand the prevention and mitigation of COVID-19.
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