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Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Updated: Jun 17, 2025

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

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Published on: May 19, 2018

A High-Throughput Screening Platform Identifies FDA-Approved Drugs That Inhibit SREBP Pathway Activation.

Chiaki T Ishida¹, Casie S Kubota¹, Evan Carlyle²

¹Department of Cell Biology, Johns Hopkins University, Baltimore, Maryland 21205 United States.

ACS Chemical Biology

|August 6, 2024

Summary

Researchers screened FDA-approved drugs to find inhibitors of Sterol Regulatory Element-Binding Proteins (SREBPs), crucial for cancer growth. They identified 13 drugs that block the SREBP pathway, offering potential new cancer therapies.

Area of Science:

Biochemistry
Molecular Biology
Oncology

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