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Updated: Jun 17, 2025
A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
Interleukin-17 as predictor mortality of septic patients: a systematic review and meta-analysis
Dwi Retnoningrum1, Budi Mulyono2, Umi Solekhah Intansari2
1UNIVERSITAS DIPONEGORO, SEMARANG, INDONESIA.
Objective:
Aim: This study aimed to prove the role of IL-17 on the clinical outcomes of septic patients.
Patients And Methods:
Materials and Methods: This study used a systematic review and meta-analysis design. Data were obtained by searching articles published between January 2001 and June 2022 in Pubmed, Science Direct, Scopus, and Medline databases to evaluate Interleukin-17 on clinical outcomes in septic patients. Only human studies were used in this study. Meta-analysis was undertaken using random effects models.
Results:
Results: Fourteen published studies were eligible, and four studies were included in the meta-analysis. Meta-analysis of the ratio of means (RoM) IL-17 concentration demonstrated a 5.96-fold higher level in non-survivor septic patients compared with survivors (four studies; n = 194 patients; RoM=5.96; 95% CI, 3.51-10.31; p < 0.00001; I2 = 92%).
Conclusion:
Conclusions: IL-17 levels were significantly elevated in non-survivor and predicted mortality of septic patients.
