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Changes in Atherosclerotic Cardiovascular Disease Risk Scores in a Predominantly Black Cohort with HIV and Associated
Shana A B Burrowes1, Erin Zisman2, Lori E Fantry3
1Section of Infectious Diseases, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Insights
Atherosclerotic cardiovascular disease (ASCVD) risk did not significantly change over 4 years in people with HIV (PWH). However, hepatitis C and dual hepatitis B/C infections were linked to higher ASCVD risk scores in this population.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- People with HIV (PWH) face a higher risk of atherosclerotic cardiovascular disease (ASCVD) than the general population.
- The underlying reasons for this elevated ASCVD risk in PWH are not fully understood.
- This study aimed to identify clinical factors associated with changes in ASCVD risk scores over time in PWH.
Purpose of the Study:
- To investigate the 4-year change in ASCVD risk scores among people with HIV (PWH).
- To identify clinical factors associated with changes in ASCVD risk scores or high-risk scores in PWH.
- To explore the impact of viral hepatitis coinfections on ASCVD risk in PWH.
Main Methods:
- Retrospective analysis of 187 people with HIV (PWH) aged 40-75.
- Calculation of ASCVD risk scores using the Pooled Cohort Equation.
- Exploratory and adjusted analyses examined changes in risk scores and associated factors over a 4-year period.
Main Results:
- No significant change in ASCVD risk scores was observed over the 4-year study period.
- ASCVD risk scores were significantly higher in PWH with hepatitis C coinfection.
- ASCVD risk scores trended higher in PWH with dual hepatitis B/C and hepatitis B coinfections.
Conclusions:
- ASCVD risk remained stable over 4 years in a predominantly Black cohort of PWH.
- Hepatitis C and dual hepatitis B/C infections are associated with increased ASCVD risk in PWH.
- Further longitudinal research is needed to understand viral hepatitis's role in cardiovascular disease risk among vulnerable populations.
Introduction:
People with HIV (PWH) have an increased risk of atherosclerotic cardiovascular disease (ASCVD) compared to non-PWH, but the reasons for this increased risk remain elusive. We investigated the change in ASCVD risk scores over 4 years to identify clinical factors associated with change in risk scores or high-risk scores.
Methods:
We conducted a preliminary study using retrospective analysis of PWH, between 40 and 75 years old, seen at the Evelyn Jordan Center with at least two routine HIV visits. We collected clinical and demographic data and calculated the ASCVD risk scores using the Pooled Cohort Equation. Exploratory analyses examined change in risk score categories over time. Final adjusted analysis examined factors associated with change in continuous risk scores over time.
Results:
Our sample included 187 PWH; 166 were black/African American and 79 were female. We found no significant change in ASCVD risk score over time. The risk score was significantly higher in PWH with hepatitis C (7.34%; 95% CI: 2.59, 12.09; p = 0.003) and trended higher in those with dual hepatitis B/C and hepatitis B compared to those without hepatitis (p = 0.07).
Conclusion:
We found that ASCVD risk did not change over a 4-year period among predominantly black young PWH, but infection with hepatitis C and dual hepatitis B/C were associated with higher ASCVD risk scores. Our findings illustrate the need for further longitudinal studies evaluating change in cardiovascular disease (CVD) risk and investigating viral hepatitis as an added potential contributor to increased CVD risk in high-risk, vulnerable populations.
Introduction:
People with HIV (PWH) have an increased risk of atherosclerotic cardiovascular disease (ASCVD) compared to non-PWH, but the reasons for this increased risk remain elusive. We investigated the change in ASCVD risk scores over 4 years to identify clinical factors associated with change in risk scores or high-risk scores.
Methods:
We conducted a preliminary study using retrospective analysis of PWH, between 40 and 75 years old, seen at the Evelyn Jordan Center with at least two routine HIV visits. We collected clinical and demographic data and calculated the ASCVD risk scores using the Pooled Cohort Equation. Exploratory analyses examined change in risk score categories over time. Final adjusted analysis examined factors associated with change in continuous risk scores over time.
Results:
Our sample included 187 PWH; 166 were black/African American and 79 were female. We found no significant change in ASCVD risk score over time. The risk score was significantly higher in PWH with hepatitis C (7.34%; 95% CI: 2.59, 12.09; p = 0.003) and trended higher in those with dual hepatitis B/C and hepatitis B compared to those without hepatitis (p = 0.07).
Conclusion:
We found that ASCVD risk did not change over a 4-year period among predominantly black young PWH, but infection with hepatitis C and dual hepatitis B/C were associated with higher ASCVD risk scores. Our findings illustrate the need for further longitudinal studies evaluating change in cardiovascular disease (CVD) risk and investigating viral hepatitis as an added potential contributor to increased CVD risk in high-risk, vulnerable populations.
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