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Accelerated Development of Pharmaceuticals Past, Present, and Future.
1Department of Industrial and Molecular Pharmaceutics, Purdue University, West Lafayette, IN, USA. sbyrn@purdue.edu.
Pharmaceutical Research
|August 6, 2024
Summary
This review explores pharmaceutical development acceleration, from 1990s strategies to current PK/PD advancements and future outlooks. It covers case studies and rapid manufacturing for vaccines and nanoparticles.
Area of Science:
- Pharmaceutical Sciences
- Drug Development
- Biotechnology
Background:
- Early pharmaceutical development relied on traditional timelines.
- The need for faster drug delivery has driven innovation.
- Historical initiatives in the 1990s laid groundwork for expedited processes.
Purpose of the Study:
- To review the evolution of accelerated pharmaceutical development.
- To analyze key strategies and case studies in drug development acceleration.
- To provide perspectives on current and future trends in rapid pharmaceutical manufacturing.
Main Methods:
- Historical analysis of drug development initiatives.
- Review of pharmacokinetic/pharmacodynamic (PK/PD) applications.
- Examination of case studies like INDIGO and Chorus programs.
- Analysis of conference proceedings (NIPTE) for industrial insights.
Main Results:
- Pharmaceutical development acceleration has evolved significantly since the 1990s.
- Pharmacokinetic/pharmacodynamic (PK/PD) modeling emerged as a key accelerator in the 2000s.
- Successful case studies demonstrate the feasibility of accelerated drug development pathways.
Conclusions:
- Accelerated pharmaceutical development requires strategic planning and adaptive methodologies.
- Current trends focus on industrial perspectives and rapid manufacturing of novel therapeutics, including vaccines and Solid Lipid Nanoparticles.
- Future pharmaceutical development will likely incorporate further technological advancements for speed and efficiency.
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