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Related Experiment Video

Updated: Jun 17, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Study protocol: perinatal mood treatment study.

Kate Wolitzky-Taylor1, Misty C Richards2, Amelia Welborn2

  • 1University of CA - Los Angeles, 405 Hilgard Ave., Los Angeles, CA, 90025, USA. kbtaylor@mednet.ucla.edu.

Trials
|August 6, 2024
PubMed
Summary
This summary is machine-generated.

This study compares a new care system (STAND) to standard care for perinatal depression. STAND aims to improve tracking and treatment of depression symptoms in pregnant and postpartum individuals.

Keywords:
Evidence-based treatmentOnline therapyPerinatal depressionTracking

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Area of Science:

  • Perinatal mental health
  • Clinical psychology
  • Reproductive psychiatry

Background:

  • Perinatal depression (PND) affects up to 20% of women, causing significant impairment and multigenerational consequences.
  • Innovative approaches are crucial for identifying, tracking, and treating PND symptoms.
  • Effective interventions are needed to reduce the public health burden of PND.

Purpose of the Study:

  • To compare the efficacy of the Screening and Treatment of Anxiety and Depression (STAND) system against standard perinatal care provided by a reproductive psychiatrist in reducing depression and anxiety symptoms.
  • To evaluate the relative effectiveness of two online therapy interventions within the STAND system.
  • To explore improved methods for tracking symptom changes, monitoring treatment response, and personalizing care for PND.

Main Methods:

  • A randomized clinical trial involving 167 participants, randomized between 28 weeks of pregnancy and 6 months postpartum.
  • Comparison of the multi-tiered STAND system of care with perinatal care delivered by a reproductive psychiatrist.
  • Secondary analysis comparing two distinct online therapy programs within the STAND intervention.

Main Results:

  • The study is designed to provide data on the relative efficacy of the STAND intervention versus standard care.
  • Results are expected to inform the effectiveness of different online therapy modalities for PND.
  • The findings will contribute to understanding optimal strategies for managing perinatal depression.

Conclusions:

  • This trial aims to establish improved methods for tracking symptom changes and monitoring treatment response in PND.
  • The study is anticipated to enhance personalized care for individuals experiencing PND.
  • Successful outcomes may lead to reduced healthcare costs and improved well-being for patients and families affected by PND.