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Related Experiment Video

Updated: Jun 17, 2025

Evaluating the Function of the Foot Core System in the Elderly

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

The ADNI PET Core at 20.

William J Jagust¹, Robert A Koeppe², Gil D Rabinovici³

¹Department of Neuroscience, University of California, Berkeley, California, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|August 7, 2024

Summary

The Alzheimer's Disease Neuroimaging Initiative (ADNI) PET Core evolved from basic glucose imaging to advanced amyloid and tau tracers. This progression has been crucial for understanding Alzheimer's disease and advancing clinical trials.

Keywords:

ADNI Alzheimer's Disease Biomarkers Alzheimer's disease PET imaging

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Area of Science:

Neuroimaging
Alzheimer's Disease Research
Positron Emission Tomography

Background:

The Alzheimer's Disease Neuroimaging Initiative (ADNI) PET Core has progressively incorporated advanced imaging techniques.
Initial studies focused on [18F]fluorodeoxyglucose (FDG)-PET, later expanding to include tracers for β-amyloid and tau pathologies.

Purpose of the Study:

To review the evolution of the ADNI PET Core's capabilities.
To highlight novel aspects of PET imaging across ADNI phases.
To provide an inventory of available PET imaging data in the ADNI database.

Main Methods:

The ADNI PET Core has standardized acquisition and analysis protocols for multitracer PET imaging.
Methods were developed to ensure feasibility across different PET scanners and multiple tracers in multi-center studies.

Main Results:

The ADNI PET Core now offers data for FDG-PET, three amyloid tracers, and three tau tracers.
Standardized methods have enabled large-scale, multi-center PET studies.
Disseminated data has been vital for Alzheimer's disease pathophysiological models and therapeutic trial methodologies.

Conclusions:

The ADNI PET Core is an invaluable resource for quantitative PET data, supporting basic and clinical research in Alzheimer's disease.
The Core's standardization efforts have facilitated modern Alzheimer's disease clinical trials.