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Glymphatic System Dysfunction in Congenital Sensorineural Hearing Loss: A DTI-ALPS Study
Li Sha1, Zhen-Gui Xu2, Yu-Chen Chen3
1Department of Pediatrics, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
Current Medical Imaging
|August 7, 2024
Summary
Glymphatic system function is reduced in children with congenital sensorineural hearing loss (CSNHL), as indicated by a lower DTI-ALPS index. This finding may help track disease progression and understand neural mechanisms in CSNHL.
Area of Science:
- Neuroscience
- Audiology
- Radiology
Background:
- Neural mechanisms of congenital sensorineural hearing loss (CSNHL) are not well understood.
- Investigating the glymphatic system offers a new perspective on CSNHL pathophysiology.
Purpose of the Study:
- To evaluate glymphatic system function in children with CSNHL using diffusion tensor imaging along the perivascular space (DTI-ALPS).
- To compare DTI-ALPS index in CSNHL patients versus healthy controls (HCs).
- To explore the relationship between glymphatic function and age in CSNHL.
Main Methods:
- Recruited 26 children with CSNHL and 30 HCs.
- Calculated the DTI-ALPS index for all participants.
- Analyzed differences in DTI-ALPS index between groups and correlated it with age in the CSNHL group.
Main Results:
- Children with CSNHL showed a significantly lower DTI-ALPS index compared to HCs (1.49 vs. 1.61, p=0.002).
- The association fiber diffusivity along the z-axis (Dzzassoc) was significantly higher in the CSNHL group (p=0.003).
- A significant negative correlation was found between the DTI-ALPS index and age in children with CSNHL (rho = -0.544, p=0.005).
Conclusions:
- This is the first study to investigate glymphatic system activity in CSNHL children using the DTI-ALPS index.
- Reduced glymphatic system function was observed in CSNHL children, correlating with age.
- The DTI-ALPS index may serve as a biomarker for CSNHL progression and treatment, aiding research into neural mechanisms of early hearing deprivation.
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