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Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
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Updated: Jul 5, 2026

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Multiple primary diffuse large B-cell lymphoma masquerading as meningioma.

Sivaraman Kumarasamy1, Kanwaljeet Garg1, Satish Kumar Verma1

  • 1Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Surgical Neurology International
|August 7, 2024
PubMed
Summary
This summary is machine-generated.

Primary non-Hodgkin's lymphoma in the brain is rare, often mimicking meningioma. This case highlights the diagnostic challenge and poor prognosis of diffuse large B-cell lymphoma (DLBCL) in immunocompetent patients.

Keywords:
Adjuvant therapyDiffuse large B-cell lymphoma (DLBCL)LymphomaNon-hodgkin’s lymphoma

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Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Primary non-Hodgkin's lymphoma with extra- and intra-calvarial extensions is exceptionally rare in immunocompetent individuals.
  • These tumors often present as mass lesions, mimicking meningioma and causing increased intracranial pressure.

Observation:

  • A young female presented with primary diffuse large B-cell lymphoma (DLBCL) involving the scalp and dura.
  • Radiological and clinical presentation mimicked meningioma, posing a diagnostic challenge.

Findings:

  • Histological examination confirmed DLBCL (germinal center type).
  • Surgical management was performed, followed by planned adjuvant therapy.

Implications:

  • Diffuse large B-cell lymphoma (DLBCL) is uncommon in neurosurgical practice and can be misdiagnosed as meningioma.
  • Early diagnosis and prompt chemotherapy are crucial for managing intracranial DLBCL, despite challenges in presentation and treatment.
  • This case underscores the aggressive nature of DLBCL and the need for vigilance in immunocompetent patients.