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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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A Long-Lasting Triamcinolone-Loaded Microneedle Patch for Prolonged Dermal Delivery.

Nasrin Zarei Chamgordani1, Sasan Asiaei2, Fatemeh Ghorbani-Bidkorpeh1

  • 1Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian Journal of Pharmaceutical Research : IJPR
|August 7, 2024
PubMed
Summary

This study developed polylactic acid microneedles for prolonged delivery of triamcinolone acetonide (TrA), offering a new approach for scar treatment and wound closure. The microneedles demonstrated effective drug release and skin penetration.

Keywords:
Drug DeliveryMicroneedleScarsSkin PermeationSolvent CastingTriamcinolone

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Area of Science:

  • Biomaterials Science
  • Dermatology
  • Drug Delivery Systems

Background:

  • Scars, resulting from wounds or burns, are aesthetically undesirable skin lesions.
  • Conventional triamcinolone treatments require frequent application for scar management.
  • Microneedle technology offers a potential for prolonged dermal drug delivery and wound closure.

Purpose of the Study:

  • To develop a polylactic acid (PLA) microneedle patch for sustained release of triamcinolone acetonide (TrA).
  • To evaluate the potential of these microneedles for wound edge closure and scar prevention/treatment.

Main Methods:

  • Fabrication of 3% and 10% TrA-loaded PLA microneedles via micro molding-solvent casting.
  • Characterization using optical microscopy, XRD, FT-IR, and DSC.
  • Evaluation of mechanical strength, insertion depth in human skin, in vitro release kinetics over 34 days, and ex vivo skin permeation.

Main Results:

  • Uniform PLA microneedles were successfully fabricated without structural defects.
  • No chemical interaction or thermal/crystallinity changes were observed between TrA and PLA.
  • Microneedles achieved penetration depths of 900-1000 μm, with sustained release following Higuchi and zero-order kinetics over 34 days.

Conclusions:

  • PLA microneedles loaded with TrA can be effectively fabricated using the solvent casting method.
  • These microneedles exhibit suitable mechanical properties and prolonged drug release profiles.
  • The developed microneedle patch shows promise for improved scar treatment and wound management.