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Updated: Jun 17, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Management of patients with concurrent clonal plasma cell and myeloid disorders: A single center descriptive case

Michael J Hochman1,2, Gloria F Gerber2, Philip H Imus1

  • 1Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States.

Leukemia Research Reports
|August 7, 2024
PubMed

Insights

Concurrent clonal plasma cell and myeloid disorders (CPCMD) present challenges. Prioritizing clone-directed therapies for genetic lesions or end-organ complications is recommended, with stepwise simultaneous treatment being a safe option.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Clonal plasma cell and myeloid disorders increase with age.
  • Concurrent clonal plasma cell and myeloid disorders (CPCMD) pose significant clinical and therapeutic challenges.

Keywords:
Malignancy precursorsMonoclonal gammopathiesMyelodysplastic syndromedual hematologic disorders

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