Interaction of salsolinol and tetrahydropapaveroline with catecholamines

Formation of aberrant amine metabolites, tetrahydroisoquinolines (TIQs) has been hypothesized to account for some of the effects of ethanol. These compounds have been shown to interact with catecholamine neurons in a variety of ways by in vitro techniques. The most interesting facet of these alkaloids, however, is the fact that they cause an increase in preference for and voluntary consumption of ethanol when administered into the ventricle of the rat in exceedingly low amounts. Investigation of the neurochemical effects in vivo of two of the TIQs tetrahydropapaveroline (THP) and salsolinol, indicates that they influence several aspects of presynaptic catecholamine function when examined acutely. The mechanism of action responsible for the radical long-lasting behavioral effects of these substances has yet to be defined.