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12:22
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
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Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior: Two case reports
Hui-Hui Cao1, Hong Li1, Xiao-Hong Guo1
1Department of Pathology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai 519000, Guangdong Province, China.
World Journal of Clinical Cases
|August 7, 2024
Summary
Eosinophilic solid and cystic renal cell carcinoma (RCC) is a rare kidney cancer. This report details two cases, one with widespread metastases, highlighting the need for better understanding and diagnosis of this emerging RCC subtype.
Area of Science:
- Oncology
- Pathology
Background:
- Eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC) is an emerging subtype of kidney cancer.
- While generally indolent, ESC RCC can rarely metastasize, necessitating further clinical investigation.
Observation:
- This report presents two distinct cases of ESC RCC.
- Case 1 involved a young woman with typical ESC RCC features.
- Case 2 presented a 52-year-old male with extensive multifocal metastases across multiple organs and lymph nodes.
Findings:
- The characteristic histopathology and immunophenotype are crucial for diagnosing ESC RCC.
- Accurate diagnosis is achievable even with core biopsy samples.
Implications:
- Increased awareness of ESC RCC aids in definitive diagnosis.
- Future research into ESC RCC molecular signatures may unveil novel therapeutic targets.
Keywords:
CK20Case reportEosinophilic solid and cystic renal cell carcinomaSolid and cystic growth patternTSC1 mutationsTSC2 mutationsMore Related Videos
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