Related Experiment Video
Updated: Jun 17, 2025
07:07
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
11.3K
Adrenaline in pulp capping treatment of reversible pulpitis
Si-Yun Yang1, Jin-Zhu Wang2, Hao Fan1
1Department of Stomatology, Anhui Jieshou People's Hospital, Fuyang 236500, Anhui Province, China.
World Journal of Clinical Cases
|August 7, 2024
Summary
Epinephrine (adrenaline) effectively treated reversible pulpitis with pulp capping, reducing pain and improving symptoms. It acts as a protective factor, unlike Streptococcus and Fusobacterium nucleatum, which are risk factors.
Area of Science:
- Dentistry
- Endodontics
- Oral Surgery
Background:
- The efficacy of epinephrine (adrenaline) in pulp capping for reversible pulpitis remains unclear.
- This study investigates the role of adrenaline in managing reversible pulpitis via pulp capping.
Purpose of the Study:
- To evaluate the therapeutic role of epinephrine in pulp capping for patients with reversible pulpitis.
- To compare the clinical outcomes and safety of adrenaline versus zinc oxide eugenol paste.
Main Methods:
- 100 patients with reversible pulpitis were divided into two groups: adrenaline (observation) and zinc oxide eugenol paste (control).
- Outcomes measured included 24-h postoperative pain, gingival healing time, clinical efficacy, and adverse reactions.
- Logistic regression analyzed factors influencing treatment success.
Main Results:
- The adrenaline group showed significantly lower 24-h postoperative pain and faster regression of gingival inflammation.
- A higher overall effective rate (94%) was observed in the adrenaline group compared to the control group (80%).
- Adrenaline was identified as a protective factor, while Streptococcus and Fusobacterium nucleatum were risk factors for treatment failure.
Conclusions:
- Adrenaline is a safe and effective agent for pulp capping in reversible pulpitis, improving pain and clinical outcomes.
- Adrenaline demonstrates protective effects, whereas anaerobic bacteria like Streptococcus and Fusobacterium nucleatum pose risks.
- Targeted interventions can enhance pulp capping treatment efficacy.
Related Concept Videos
01:30Adrenergic Agonists: Therapeutic Uses
757
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
757
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
164
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
164
01:16Antianginal Drugs: Nitrates and β-Blockers
557
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
557
01:26Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
151
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
151
01:18Drug Delivery: Enteral Route
406
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
406
01:17Increased pulse rate
651
Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
651