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Biomedical SERS - the current state and future trends.

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Summary
This summary is machine-generated.

Surface enhanced Raman spectroscopy (SERS) offers a sensitive and specific tool for biomedical applications. This review covers SERS sample preparation, detection methods, and active surfaces for point-of-care diagnostics.

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Area of Science:

  • Biomedical Science
  • Analytical Chemistry
  • Spectroscopy

Background:

  • Surface enhanced Raman spectroscopy (SERS) is a highly sensitive and specific analytical technique.
  • Portable Raman systems and tailored sample preparation enable point-of-care-testing (POCT).
  • Stable SERS-active surfaces are available for complex biological matrices like body fluids and cells.

Purpose of the Study:

  • To review current SERS protocols for sample collection and pretreatment in biomedical applications.
  • To summarize SERS detection schemes, including direct, indirect, targeted, and non-targeted methods.
  • To highlight recent advances in SERS for disease diagnostics and drug monitoring.

Main Methods:

  • Review of literature on SERS sample handling and preparation techniques.
  • Analysis of different SERS detection strategies and active sensing surfaces.
  • Compilation of SERS applications in infectious diseases, cancer diagnostics, and therapeutic drug monitoring.

Main Results:

  • SERS is a viable tool for POCT in biomedicine with appropriate sample preparation and sensing surfaces.
  • Various SERS detection schemes and substrates are suitable for different biological samples.
  • SERS shows significant progress in diagnosing diseases and monitoring drug levels.

Conclusions:

  • This review provides a guide to selecting optimal SERS protocols, substrates, and detection strategies for specific biomedical applications.
  • SERS technology is advancing for widespread use in clinical diagnostics and personalized medicine.
  • Understanding SERS methodologies is crucial for its effective implementation in healthcare settings.