Related Experiment Video
Updated: Jun 17, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Device therapy for heart failure management
Fouad Chouairi1, Allison Levin2, Marat Fudim2,3,4
1Department of Medicine.
Insights
Cardiologists must stay updated on new heart failure (HF) device therapies. Emerging devices offer innovative treatments, including options for heart failure with preserved ejection fraction (HFpEF).
Area of Science:
- Cardiology
- Biomedical Engineering
- Medical Devices
Background:
- Heart failure (HF) is a prevalent condition requiring interdisciplinary management.
- Device therapy for HF is rapidly evolving, necessitating physician awareness.
Purpose of the Study:
- To provide a practical overview of current and emerging device-based therapies for heart failure.
- To highlight the importance of understanding these devices for cardiologists.
Main Methods:
- Review of current literature on device development for HF.
- Categorization of devices based on their therapeutic targets and mechanisms of action.
Main Results:
- A diverse range of HF devices are in development, targeting various pathophysiological aspects.
- Innovations include remote monitoring, interatrial shunts, left ventricular structural modification, and autonomic nervous system modulation.
- Novel devices are emerging for heart failure with preserved ejection fraction (HFpEF).
Conclusions:
- There has been significant growth in device-based HF treatments.
- Physicians need to be knowledgeable about the mechanisms and applications of these new devices.
Purpose Of Review:
Given the prevalence of heart failure (HF) and the interdisciplinary nature of device therapy, it is paramount that cardiologists not only understand the current landscape of goal-directed medical therapy, but also the ongoing efforts in device development. Thus, we aim to provide a practical overview of the broad approaches being utilized in the burgeoning field of device-based therapies for heart failure.
Recent Findings:
Currently, a diverse array of devices for HF treatment is being developed and tested, each targeting distinct aspects of HF pathophysiology. These innovative solutions encompass a wide spectrum, ranging from devices enabling remote monitoring of HF associated physiological parameters, to those focused on creating interatrial shunts and effecting structural modifications of the left ventricle, as well as to those designed to modulate the autonomic nervous system and diaphragm. Notably, a subset of these emerging devices is directed towards treating patients with heart failure with preserved ejection fraction, a population that has traditionally not been served by device-based therapies.
Summary:
In recent decades, there has been a remarkable surge in the development and utilization of device-based treatments for managing HF. It is important for physicians to be familiar with these devices, their mechanisms of action, and their applications.
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