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Updated: Jul 14, 2026

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain
Published on: July 29, 2007
[Modified Masquelet technique : Technique of the induced membrane in the course of time]
C Fischer1,2, S Schipper3,4, S Langwald3
1Klinik für Unfall- und Wiederherstellungschirurgie, BG Klinikum Bergmannstrost Halle, Merseburger Straße 165, 06112, Halle (Saale), Deutschland. christian.fischer@bergmannstrost.de.
Abstract:
The reconstruction of long bone defects as a result of primary traumatic, secondary infection or tumor-related loss of substance continues to represent a surgical challenge. Callus distraction via segment transport, vascularized bone transfer and the induced membrane technique (IMT) are established methods of reconstruction. In recent decades IMT has experienced increasing popularity due to its practicability, reproducibility and reliability. At the same time, the original technique has undergone numerous modifications. The results are correspondingly heterogeneous. This overview is intended to explain the basic principles of IMT and to provide an overview of the various modifications and their complications.

