Related Experiment Video

Updated: Jun 17, 2025

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

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LAMB3: Central role and clinical significance in neoplastic and non-neoplastic diseases

Fangqiu Yu1, Guoqiang Zeng1, Lei Yang1

  • 1Urological Department, First Hospital of Jilin University, Changchun, Jilin Province 130021, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 7, 2024
PubMed

Insights

Laminin subunit beta 3 (LAMB3) is a key protein involved in cell functions. Its altered expression in various diseases suggests LAMB3 as a potential diagnostic and therapeutic target for gene therapy.

Area of Science:

  • Molecular biology
  • Genetics
  • Oncology

Background:

  • Gene signaling pathways are critical in disease progression.
  • Identifying precise gene targets is essential for effective disease treatment.
  • Laminin subunit beta 3 (LAMB3) is an extracellular matrix protein vital for cell regulation.

Purpose of the Study:

  • To review the current research status of LAMB3.
  • To explore the role of LAMB3 in various disease conditions.
  • To evaluate LAMB3 as a potential molecular target for diagnosis and therapy.

Main Methods:

  • Literature review of studies on LAMB3 expression and function.
  • Analysis of LAMB3 involvement in different pathological conditions.
  • Synthesis of research findings on LAMB3's role in gene signaling pathways.

Main Results:

  • LAMB3 is highly expressed in numerous cancers (e.g., skin, lung, breast) and conditions like renal fibrosis.
  • Conversely, LAMB3 is underexpressed in diseases such as hepatocellular carcinoma and epidermolysis bullosa.
  • LAMB3's expression pattern varies significantly across different diseases.

Conclusions:

  • LAMB3 plays a significant role in cell proliferation, migration, and cell cycle.
  • The differential expression of LAMB3 in various diseases highlights its potential as a biomarker.
  • LAMB3 represents a promising molecular target for developing targeted gene therapies and diagnostic tools.
Keywords:
Clinical significanceDisease diagnosisLAMB3Signaling pathwayTherapeutic targetUpregulated gene

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