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  1. Home
  3. Association Of Myostatin With Complications And Cognition In Lung Cancer Patients With Sarcopenia.
  1. Home
  3. Association Of Myostatin With Complications And Cognition In Lung Cancer Patients With Sarcopenia.

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Association of Myostatin With Complications and Cognition in Lung Cancer Patients With Sarcopenia.

Yang Zhang1, Rui Liu2, Wei Wang3

  • 1Department of Anesthesiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

The Journal of Surgical Research
|August 7, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Elevated myostatin (MSTN) levels in older patients undergoing thoracoscopic lobectomy correlate with increased postoperative pulmonary complications (PPCs) and cognitive impairment. MSTN can predict these risks, aiding in prevention strategies.

Keywords:
Cognitive functionMyostatinPostoperative pulmonary complicationsSarcopeniaThoracoscopic lobectomy

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Area of Science:

  • Geriatric Medicine
  • Thoracic Surgery
  • Biochemistry

Background:

  • Sarcopenia and frailty significantly increase surgical risks and postoperative complications in older adults.
  • Myostatin (MSTN) is a key regulator of muscle mass and function, and its role in surgical outcomes is under investigation.

Purpose of the Study:

  • To explore the correlation between myostatin (MSTN) levels and cognitive function in older patients undergoing thoracoscopic lobectomy.
  • To investigate the association between MSTN levels and postoperative pulmonary complications (PPCs).
  • To determine if MSTN can predict the risk of postoperative complications and cognitive impairment.

Main Methods:

  • A prospective observational study involving 122 patients undergoing thoracoscopic lobectomy.
  • Backward stepwise logistic regression analysis to identify risk factors for PPCs and cognitive impairment.
  • Patients were grouped into low-level and high-level MSTN groups based on preoperative cut-off values (25.55 ng/mL for cognitive dysfunction, 22.29 ng/mL for PPCs) for comparison.

    • Main Results:

    • Preoperative MSTN levels were confirmed as a significant risk factor for both postoperative cognitive dysfunction and PPCs.
    • Patients in the high-level MSTN group exhibited significantly higher rates of cognitive impairment, respiratory tract infections, hypoxemia, and respiratory failure.
    • Elevated MSTN levels were associated with increased hospital stay and decreased Barthel Index scores.

    Conclusions:

    • Myostatin (MSTN) can serve as a predictive index for complications and cognitive impairment following thoracoscopic lobectomy in older patients with sarcopenia.
    • These findings provide evidence for utilizing MSTN levels to mitigate postoperative cognitive impairment and PPCs.