Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

551
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
551

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same author

A human-specific enhancer fine-tunes radial glia potency and corticogenesis.

Nature·2025
Same author

Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition.

Neuron·2025
Same author

A human-specific enhancer fine-tunes radial glia potency and corticogenesis.

bioRxiv : the preprint server for biology·2024
Same author

Audiovisualization of real-time neuroimaging data.

PloS one·2024
Same author

Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Jun 17, 2025

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.1K

Human-specific genetic modifiers of cortical architecture and function.

Hanzhi T Zhao1, Ewoud Re Schmidt1

  • 1Department of Neuroscience, Medical University of South Carolina, Suite 403 BSB, MSC510, 173 Ashley Ave, Charleston, SC 29425, USA.

Current Opinion in Genetics & Development
|August 7, 2024
PubMed
Summary

Human brain evolution, particularly the cerebral cortex, is linked to cognitive abilities. Recent studies investigate how human-specific genetic modifiers impact cortical circuits and behavior, seeking a neurobiological basis for cognition.

More Related Videos

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification
11:44

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Published on: March 24, 2023

3.5K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

3.9K

Related Experiment Videos

Last Updated: Jun 17, 2025

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.1K
Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification
11:44

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Published on: March 24, 2023

3.5K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

3.9K

Area of Science:

  • Neuroscience
  • Evolutionary Biology
  • Genetics

Background:

  • The evolution of the cerebral cortex is crucial for human cognitive abilities.
  • Key evolutionary changes include increased neuron number, connectivity, and altered neuronal morpho-electric properties.
  • Human-specific genetic modifiers (HSGMs) are implicated in shaping cortical architecture.

Purpose of the Study:

  • To examine the impact of HSGMs on cortical circuit function and behavior.
  • To explore the link between cortical evolution and the emergence of human cognition.
  • To provide a neurobiological foundation for understanding human cognitive abilities.

Main Methods:

  • Review of recent studies investigating HSGMs.
  • Analysis of research on cortical circuit function and behavior.
  • Synthesis of findings on the relationship between cortical architecture and cognition.

Main Results:

  • HSGMs play a role in modifying cortical architecture.
  • These genetic changes influence cortical circuit function and behavior.
  • Evidence suggests a connection between evolutionary changes and cognitive emergence.

Conclusions:

  • Understanding HSGMs is key to deciphering the neurobiological basis of human cognition.
  • Further research is needed to link cortical evolution directly to functional and computational properties of neuronal circuits.
  • This work highlights the importance of evolutionary genetics in understanding human cognitive uniqueness.