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Lactylation: Linking the Warburg effect to DNA damage repair
Peng Sun1, Leina Ma1, Zhimin Lu2
1Department of Hepatobiliary and Pancreatic Surgery, Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266000, China.
Abstract:
In this issue of Cell Metabolism, Li et al. report that the highly expressed aldehyde dehydrogenase 1 family member A3 interacts with pyruvate kinase M2 (PKM2) in glioblastoma cells. Consequently, PKM2 tetramerization and activation promote lactate production, leading to the lactylation and nuclear translocation of XRCC1 for DNA damage repair and therapeutic resistance.
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