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Canonical Wnt Signaling Pathway02:54

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Updated: Jun 17, 2025

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Podoplanin and its multifaceted roles in mammalian developmental program.

Yi Ying Cheok1, Grace Min Yi Tan1, Yee Teng Chan1

  • 1Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.

Cells & Development
|August 7, 2024
PubMed
Summary

Podoplanin is essential for mammalian development, regulating organ formation and survival. Its absence leads to embryonic lethality, highlighting its critical role in early life processes.

Keywords:
CLEC2Central nervous systemHeart and lung organogenesisLymphangiogenesisPodoplanin

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Immunology

Background:

  • Podoplanin is a key molecule involved in development, immunity, and cancer.
  • Its expression is observed during early mammalian embryonic development.
  • Podoplanin is crucial for the morphogenesis of various organ systems.

Purpose of the Study:

  • To review the gene and protein structure of Podoplanin.
  • To elucidate the diverse functions of Podoplanin across different biological systems.

Main Methods:

  • Literature review of existing research on Podoplanin.
  • Analysis of experimental animal models with Podoplanin absence.

Main Results:

  • Podoplanin absence in animal models leads to embryonic lethality or neonatal death.
  • Podoplanin plays a role in the development of the central nervous, respiratory, lymphatic, and cardiovascular systems.

Conclusions:

  • Podoplanin is indispensable for mammalian embryonic development and survival.
  • Understanding Podoplanin's structure and function is vital for developmental and cancer research.